Comparative study on the larvicidal activity of drimane sesquiterpenes and nordrimane compounds against drosophila melanogaster til-til

Ivan Montenegro, Luis Pino, Enrique Werner, Alejandro Madrid, Luis Espinoza, Luis Moreno, Joan Villena, Mauricio Cuellar

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Natural compounds from Drimys winteri Forst and derivatives exhibited larvicidal effects against Drosophila melanogaster til-til. The most active compound was isodrimenin (4). The highest lethal concentration to the larvae of D. melanogaster was 4.5 ± 0.8 mg/L. At very low concentrations drimenol (1), confertifolin (3), and drimanol (5) displayed antifeedant and larvae growth regulatory activity. The antifeedant results of nordrimanic and drimanic compounds were better in first instar larvae. The EC50 value of polygodial (2) was 60.0 ± 4.2 mg/L; of diol 15 45.0 ± 2.8 mg/L, and of diol 17 36.9 ± 3.7 mg/L, while the new nordrimane compound 12 presented a value of 83.2 ± 3.5 mg/L. © 2013 by the authors.
Original languageEnglish
Pages (from-to)4192-4208
Number of pages17
JournalMolecules
DOIs
Publication statusPublished - 1 Apr 2013

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